Oleanolic Acid Restores Drug Sensitivity in Sorafenib-resistant Hepatocellular Carcinoma: Evidence from <i>In Vitro</i> and <i>In Vivo</i> Studies
Oleanolic acid shows promise as an adjunct therapy for overcoming sorafenib resistance in HCC. By reducing cell aggressiveness and restoring drug sensitivity, OA may enhance the therapeutic efficacy of current treatments for advanced HCC.
Authors
- Didi Wang (ORCID: https://orcid.org/0000-0002-0813-755X)
- Jinghua Ren (ORCID: https://orcid.org/0000-0002-6931-0766)
- Pengxia Zhang (ORCID: https://orcid.org/0000-0002-6114-1080)
- Tao Zhang (ORCID: https://orcid.org/0000-0003-1048-4443)
- Tongtong Li (ORCID: https://orcid.org/0009-0001-6370-7332)
- Wang Wang (ORCID: https://orcid.org/0000-0001-9093-412X)
- X. Y. Shen (ORCID: https://orcid.org/0009-0007-7342-2617)
Institutions
- Jiamusi University (CN)
- Jiangsu Vocational College of Medicine (CN)
Publication Details
- Journal
- Journal of Clinical and Translational Hepatology
- Published
- 2025-04-18
- DOI
- https://doi.org/10.14218/jcth.2024.00369
- Primary Topic
- Hepatitis C virus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00