Mechanochemical Sequential Deoxygenative Cross-Coupling Reactions of Phenols Under Ruthenium-Nickel Catalysis
Herein, we report the first mechanochemical strategy for the Ru-catalyzed deoxygenative borylation of free phenols via C-O bond cleavage. This Ru-catalyzed phenolic borylation approach has been successfully extended to the Suzuki-Miyaura-type cross-coupling of phenols with aryl bromides. The protocol accepts a wide scope of phenolic substrates, allowing the synthesis of aryl pinacolboranes and biphenyl structures in excellent yields and serving as a better alternative to classical cross-coupling reactions in the context of pot, atom, and step economy synthesis.
Authors
- Vitaliy Yepishev
- Sehrish Sarfaraz (ORCID: https://orcid.org/0000-0002-1286-9331)
- Ronak V. Prajapati (ORCID: https://orcid.org/0000-0002-6945-6925)
- Viktor O. Iaroshenko (ORCID: https://orcid.org/0000-0002-5647-5326)
- Khurshid Ayub (ORCID: https://orcid.org/0000-0003-0990-1860)
- Yevhen Karpun (ORCID: https://orcid.org/0000-0003-1816-812X)
- Vaibhav D. Prajapati (ORCID: https://orcid.org/0000-0002-0389-5925)
- Satenik Mkrtchyan (ORCID: https://orcid.org/0000-0001-7081-9802)
- Michał Jakubczyk (ORCID: https://orcid.org/0000-0002-6277-5800)
- Gabriela Addová (ORCID: https://orcid.org/0000-0003-3534-309X)
- Juraj Filo (ORCID: https://orcid.org/0000-0002-3995-2565)
- Vishal B. Purohit (ORCID: https://orcid.org/0000-0002-9392-8136)
- Michael G. Garcia
- Manoj K. Saini (ORCID: https://orcid.org/0000-0003-2142-8578)
Institutions
- Osnabrück University (DE)
- Gulf University for Science & Technology (KW)
- Abbottabad University of Science and Technology (PK)
- Charotar University of Science and Technology (IN)
- Czech Academy of Sciences, Institute of Inorganic Chemistry (CZ)
- Georgian American University (GE)
- Sardar Patel University (IN)
- Matej Bel University (SK)
- Chitkara University (IN)
- Comenius University Bratislava (SK)
- Banaras Hindu University (IN)
Publication Details
- Journal
- Molecules
- Published
- 2025-04-19
- DOI
- https://doi.org/10.3390/molecules30081835
- Citations
- 4
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- Agentúra na Podporu Výskumu a Vývoja