Phenotypic patterns of metabolic dysfunction‐associated steatotic liver disease in type 2 diabetes: The impact of insulin
Two new MASLD-T2D phenotypes have been identified, HepGluc[+] and HepGluc[-], according to IGLU patterns, with HepGluc[+] being more deleterious due to higher systemic IR, steatosis and inflammation. Phenotypes can be identified using a new function, the MASLD-T2D score.
Authors
- Albert Roque (ORCID: https://orcid.org/0000-0001-9738-3850)
- H Cuellar (ORCID: https://orcid.org/0000-0003-2197-4990)
- Jaume Baguñà
- Miguel Á. González Ballester (ORCID: https://orcid.org/0000-0002-9227-6826)
- Clara Ramírez (ORCID: https://orcid.org/0000-0001-8971-1711)
- Queralt Martín‐Saladich (ORCID: https://orcid.org/0000-0003-4798-1558)
- José Raúl Herance (ORCID: https://orcid.org/0000-0001-7178-3290)
- Juan M. Pericàs (ORCID: https://orcid.org/0000-0002-3645-3293)
- Santiago Aguadé‐Bruix (ORCID: https://orcid.org/0000-0001-8617-6274)
- Andreea Ciudin (ORCID: https://orcid.org/0000-0001-5622-0203)
- Rafael Simó (ORCID: https://orcid.org/0000-0003-0475-3096)
- María Nazarena Pizzi
- Nuria Roson‐Gradaille
Institutions
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Universitat Pompeu Fabra (ES)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
Publication Details
- Journal
- European Journal of Clinical Investigation
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1111/eci.70050
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Fundació Institut de Recerca Hospital Universitari Vall d’Hebron
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Instituto de Salud Carlos III