RISK FACTORS AND CLINICAL FEATURES OF COMORBID ATOPIC DERMATITIS IN CHILDREN

Atopic dermatitis is a multifactorial disease caused by the combined effects of genetic changes and trigger mechanisms in the body. It is known that the etiopathogenetic "basis" of multifactorial diseases is the creation of a certain polymorphic form of functionally defective genes (genetic "predispositions", candidate genes, mediator genes) that have a detrimental effect on the environment. Based on historical sources, atopic dermatitis is an "abnormal" genetically determined reaction of the body to inhalation and food allergens, characterized by an increase in the amount of immunoglobulin E (IgE) and specific IgE antibodies in response. In our current work, we will consider the origin of atopic dermatitis and its relationship with other allergic diseases. Risk factors for comorbidity are identified. Materials and methods of the study. The study included 130 children aged 6 to 12 years with bronchial asthma and AtD, who underwent inpatient treatment at the multidisciplinary clinic of the Tashkent Medical Academy in 2019-2024. Study results. Medical, biological and social risk factors for the development of atopic dermatitis in comorbidity with bronchial asthma were identified; the significance of determining the amount of Cys-LT in urine for the early diagnosis of atopic dermatitis in comorbidity with bronchial asthma was established; a method for the early diagnosis of atopic dermatitis in comorbidity with bronchial asthma was developed, a treatment method was improved, the effectiveness of which is based on the determination of leukotrienes in urine and specific IgE in the blood. Conclusion. Based on the obtained scientific results on the identification of clinical manifestations of atopic dermatitis comorbid with bronchial asthma, improvement of diagnostic and treatment methods: optimization of treatment methods and their use at the primary stage in the comorbid course of atopic dermatitis with bronchial asthma in children.