FEATURES OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH COMBINED PATHOLOGY OF BRONCHIAL ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Introduction. Mortality from respiratory infections (ARI) has always been high, and is included in the list of the 10 leading causes of death of the world's population according to the World Health Organization[1,9,10]. Bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) are pathologies of the respiratory tract characterized by chronic bronchial obstruction. Both diseases occur due to the interactions of environmental factors and the human body, which lead to a wide range of clinical manifestations. The aim of the study was to evaluate the role of nitric oxide metabolites in the formation of endothelial dysfunction in patients with bronchial asthma, chronic obstructive pulmonary disease and their combination. Research materials and methods: 115 patients and 20 healthy volunteers were examined at the Department of Pulmonology and Allergology of the Samarkand City Medical Association. Results and conclusions. To identify endothelial dysfunction, we studied the ratio of NO2 and NO3 indicators both in the composition of the CV and in the blood. The results showed that patients with COPD +ASTHMA had increased concentrations of NO2 and NO3 compared with the isolated course of the disease (P<0.05; P<0.001) both in the acute and remission stages, which confirmed a high level of endothelial system dysfunction in the combined course of the disease.