THE EFFECTS OF SIDR HONEY ON HEPATOTOXICITY IN RATS EXPOSED TO SIDESTREAM CIGARETTE SMOKE

This work aimed to use Sidr honey (SHY) for the reduction of the acute effects of sidestream cigarette smoke (SCS) on the liver tissues of rats.24 rats were divided into 4 groups: (G1) control group; (G2) rats were administered orally SHY (100 mg/kg BW/30 days; (G3) rats were exposed to the SCS for a one month, and (G4) rats were taken the SHY 100 mg/kg BW/ 14 days before the rats were exposed to SCS for a one month.The mean AST, ALT, ALP, and cholesterol values were significantly higher in the G3 than in the G1.In contrast, the G4 showed a significant decline compared to the G3 rats.Moreover, the albumin, total protein, and HDL levels showed an important reduction in the G3 compared to G1.However, these parameters improved after treatment with honey in the G4 compared to the G3.Also, the liver tissue of G4 had some histological changes and a moderate improvement in the tissue's structure compared to G3.Moreover, the G3 showed the collagen fibers meaningfully augmented in the central vein wall and portal area, while the G4 presented as nearly similar to the G1.Therefore, this study confirmed the beneficial effects of SHY in lowering hepatotoxicity in rats exposed to SCS for one month..