RADIATION FRAGMENTATION AND BIOLOGICAL ACTIVITY OF TABLETED DRUG IRRADIATED ON THE M-30 MICROTRON

The results of the study of fragmentation of tableted aspirin without and after irradiation of the fast electrons of 18 MeV on the M-30 microtron are presented. The peculiarities of tablet fragmentation were studied by mass spectrometry from the aqueous phase; the data obtained show a significant effect of radiation treatment of tablets on the structure of their mass spectra. It was found that radiation destruction of the material of the active ingredient of tablets and its accompanying components, filler, coating, etc., affects the drug's biological activity. Using four test microorganisms from different phylogenetic groups, the selectivity of the antibacterial or stimulant effect of the tablets immediately after irradiation and in the time of evolution was shown.