The Comprehensive Review on Role of Niosomal Gels and Its Method of preparation

Niosomal gels enhance skin penetration by acting as a carrier system, improving drug solubility and bioavailability, and allowing for sustained release of encapsulated active ingredients.Niosomes are lipid-based vesicles, similar to liposomes, but they are made from non-ionic surfactants instead of phospholipids.They are multi-lamellar vesicles that can efficiently transfer active substances to epidermal layers or circulation.Niosomes can encapsulate both hydrophilic and hydrophobic drugs.Niosomal gels can be used for transdermal drug delivery, where drugs are absorbed into the bloodstream through the skin.Niosomes are multilamellar vesicles that efficiently transfer active substances to epidermal layers or circulation.They improve "active drug skin penetration in topical drug delivery systems.The goal of this work was to develop a luliconazole (LCZ) niosomal gel to promote skin permeability.Luliconazole treats tinea pedis, cruris, and corporis caused by Epidermophyton floccosum and Trichophyton rubrum.Luliconazole has improved skin pharmacokinetics.In the all formulations, the cholesterol ratio was consistent and was prepared by ether injection method using span 60 or tween 80 surfactants.