The role of cytokine licensing in shaping the therapeutic potential of wharton’s jelly MSCs: metabolic shift towards immunomodulation at the expense of differentiation
Our findings demonstrate that TNF-α/IFN-γ priming reprograms WJ-MSCs by enhancing their immunomodulatory capacity at the expense of differentiation potential. These results highlight the need for tailored strategies to optimize MSC functionality for specific clinical applications.
Authors
- Yuriy Petrenko (ORCID: https://orcid.org/0000-0002-7264-8784)
- Michal Šíma (ORCID: https://orcid.org/0000-0001-6927-8615)
- Irena Vacková (ORCID: https://orcid.org/0000-0001-8298-5680)
- Jarmila Havelkova (ORCID: https://orcid.org/0009-0007-3803-909X)
- Pavel Abaffy (ORCID: https://orcid.org/0000-0002-7571-8880)
- Lucie Bačáková (ORCID: https://orcid.org/0000-0002-1818-9484)
- Klára Gotvaldová (ORCID: https://orcid.org/0000-0002-0774-4454)
- Katarína Smolková (ORCID: https://orcid.org/0000-0002-4734-0200)
- Šárka Kubinová (ORCID: https://orcid.org/0000-0003-1674-4779)
- Pavla Jendelová (ORCID: https://orcid.org/0000-0002-4644-9212)
- Eliska Vavrinova (ORCID: https://orcid.org/0000-0001-7765-3569)
- Pavel Rössner (ORCID: https://orcid.org/0000-0001-6921-5446)
- Olena Rogulska (ORCID: https://orcid.org/0000-0002-4757-0241)
Institutions
- Czech Academy of Sciences (CZ)
- Charles University (CZ)
- Czech Academy of Sciences, Institute of Biotechnology (CZ)
- FZU ‒ Institute of Physics of the Academy of Sciences of the Czech Republic (CZ)
- Czech Academy of Sciences, Institute of Experimental Medicine (CZ)
- Czech Academy of Sciences, Institute of Physiology (CZ)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-04-20
- DOI
- https://doi.org/10.1186/s13287-025-04309-2
- Citations
- 3
- Primary Topic
- Exercise and Physiological Responses
- Type
- article
- Field-Weighted Citation Impact
- 3.08
Funders
- Ministerstvo Školství, Mládeže a Tělovýchovy
- Grantová Agentura České Republiky
- Ministerstvo Zdravotnictví Ceské Republiky
- Akademie Věd České Republiky
- Agentura Pro Zdravotnický Výzkum České Republiky