Footprint-free induced pluripotent stem cells can be successfully differentiated into mesenchymal stromal cells in the feline model
We demonstrated the generation of footprint-free iPSCs from domestic cats and their directed differentiation potential towards MSCs. These SeV-derived feline iPSCs and iPSC-derived MSCs will provide valuable models to study feline diseases and explore novel therapeutic strategies and can serve as translational models for human health, leading to increased knowledge on disease pathogenesis and improved therapeutic interventions.
Authors
- Rebecca Mattingly Harman (ORCID: https://orcid.org/0000-0003-4213-1933)
- Mason Jager (ORCID: https://orcid.org/0000-0001-6036-9895)
- Gerlinde R. Van de Walle (ORCID: https://orcid.org/0000-0002-2064-8029)
- Prasanna Weeratunga (ORCID: https://orcid.org/0000-0001-6366-7628)
Institutions
- Roslin Institute (GB)
- Cornell University (US)
- New York State College of Veterinary Medicine (US)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-04-20
- DOI
- https://doi.org/10.1186/s13287-025-04325-2
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cornell Feline Health Center