Neural-induced human adipose tissue-derived stem cell secretome exerts neuroprotection against rotenone-induced Parkinson’s disease in rats
NI-hADSC-CM and NI-hADSC-Exo significantly exerted neuroprotection by decreasing α-syn toxicity, inhibiting neuroinflammation and apoptosis, restoring autophagic flux properties, and promoting the neuronal function in ROT-injected rats; however, the influence of these treatments on signaling pathways differed slightly between the midbrain and striatum regions. Targeting α-syn degradation pathways provides a novel strategy to elucidate the beneficial effects of MSC secretome and future safe cell-free treatments for PD.
Authors
- Byeong C. Kim (ORCID: https://orcid.org/0000-0001-6827-6730)
- Han‐Seong Jeong (ORCID: https://orcid.org/0000-0001-6921-6625)
- Jinsu Hwang (ORCID: https://orcid.org/0009-0008-0672-3601)
- Hyong‐Ho Cho (ORCID: https://orcid.org/0000-0002-1331-4039)
- Sujeong Jang (ORCID: https://orcid.org/0000-0001-8673-7887)
- Mahesh Ramalingam (ORCID: https://orcid.org/0000-0002-8831-4375)
Institutions
- Chonnam National University Hospital (KR)
- Chonnam National University Hwasun Hospital (KR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-04-20
- DOI
- https://doi.org/10.1186/s13287-025-04306-5
- Citations
- 6
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- Korea Institute for Advancement of Technology
- Korea Health Industry Development Institute
- National Research Foundation of Korea