Probiotic treatment induces sex-dependent neuroprotection and gut microbiome shifts after traumatic brain injury
Our findings indicate that PP administration modulates microbiome composition, reduces neuroinflammation, and improves motor deficits following TBI, with these effects being particularly pronounced in male mice.
Authors
- Sonia Villapol (ORCID: https://orcid.org/0000-0002-6174-4113)
- Austin Marshall (ORCID: https://orcid.org/0000-0001-5749-1558)
- Sirena Soriano (ORCID: https://orcid.org/0000-0001-9967-7262)
- Todd J. Treangen (ORCID: https://orcid.org/0000-0002-3760-564X)
- Morgan Holcomb (ORCID: https://orcid.org/0009-0001-1902-7882)
- Hannah Flinn
- Fernando Gómez‐Pinilla
- Mariana Lozano-Cavazos
Institutions
- Houston Methodist (US)
- University of California, Los Angeles (US)
- Cornell University (US)
- Kennedy Center (DK)
- Rice University (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-04-20
- DOI
- https://doi.org/10.1186/s12974-025-03419-1
- Citations
- 16
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 12.09
Funders
- Cancer Prevention and Research Institute of Texas
- Dan L. Duncan Cancer Center, Baylor College of Medicine
- National Institutes of Health
- Houston Methodist Research Institute
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke