Optimizing paracetamol-ascorbic acid effervescent tablet characteristics: a quality by design approach
The study successfully optimized the hardness, disintegration, and dissolution rate of PCM-AA effervescent tablets via the QbD approach. Granulation time affects hardness and PCM dissolution, binder concentration influences disintegration time, and the effervescent agents' ratio impacts both disintegration time and AA dissolution. This research enhances the understanding of pharmaceutical formulation processes, risk management, and optimization in effervescent tablet development.
Authors
- Shaiqah Mohd Rus
- Muhammad Salahuddin Haris (ORCID: https://orcid.org/0000-0003-4708-4603)
- Bappaditya Chatterjee (ORCID: https://orcid.org/0000-0003-1816-6028)
- Nur Tasnim Adlina Mazdi
- Nur Aisyah Mior Mat Zin
- Muhammad Aiman Khairul Hisham
Institutions
- International Islamic University Malaysia (MY)
- University of Kuala Lumpur (MY)
- GITAM University (IN)
- Royal College of Physicians and Surgeons of Canada (CA)
Publication Details
- Journal
- Drug Development and Industrial Pharmacy
- Published
- 2025-04-20
- DOI
- https://doi.org/10.1080/03639045.2025.2495131
- Citations
- 1
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 1.56