Clustered Carbon Nanotubes Damage Endoplasmic Reticulum

Carbon nanotubes (CNTs) have garnered significant attention in recent years due to their unique properties and their wide-range applicability. However, alongside these promising applications, concerns regarding the potential toxicity of CNTs have emerged. In this context, through this work, we have attempted to explore the nanotoxic effect of CNTs over endoplasmic reticular (ER). Using structure illumination and transmission electron microscopies, we unveiled that during endocytosis processes, CNTs form clusters, which lead to fragmentation of the ER structure by puncturing them, thereby inducing potential nanotoxicity. In addition, RNA sequencing data showed that after incubation with CNTs, activating transcription factor 4 (ATF4), a gene responsible for ER stress, was found to be up-regulated. To explore the molecular mechanism, we employed molecular dynamics and coarse-grained simulations and found that clustering of CNTs can significantly increase the speed of lipid extraction, resulting in severe damage.

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Publication Details

Journal
ACS Applied Materials & Interfaces
Published
2025-04-20
DOI
https://doi.org/10.1021/acsami.5c03796
Citations
3
Primary Topic
Graphene and Nanomaterials Applications
Type
article
Field-Weighted Citation Impact
2.02

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article

Clustered Carbon Nanotubes Damage Endoplasmic Reticulum

Dechang Li, Baohua Ji, Zhou Fang, Kangqiang Qiu et al.
3 citations
ACS Applied Materials & Interfaces
Graphene and Nanomaterials Applications
2.02
article

Clustered Carbon Nanotubes Damage Endoplasmic Reticulum

Dechang Li, Baohua Ji, Zhou Fang, Kangqiang Qiu, Aditya Yadav, Adrian Y. Tan, Jiajie Diao, Xiang Zhang, Yuxin Wang, Zihan Tang
article en
3 citations

Abstract

Carbon nanotubes (CNTs) have garnered significant attention in recent years due to their unique properties and their wide-range applicability. However, alongside these promising applications, concerns regarding the potential toxicity of CNTs have emerged. In this context, through this work, we have attempted to explore the nanotoxic effect of CNTs over endoplasmic reticular (ER). Using structure illumination and transmission electron microscopies, we unveiled that during endocytosis processes, CNTs form clusters, which lead to fragmentation of the ER structure by puncturing them, thereby inducing potential nanotoxicity. In addition, RNA sequencing data showed that after incubation with CNTs, activating transcription factor 4 (ATF4), a gene responsible for ER stress, was found to be up-regulated. To explore the molecular mechanism, we employed molecular dynamics and coarse-grained simulations and found that clustering of CNTs can significantly increase the speed of lipid extraction, resulting in severe damage.

ACS Applied Materials & InterfacesVol. 17(17)
Biomechanics Institute of Valencia (ES), Division of Materials Science and Engineering (AU), University of Cincinnati (US), Zhejiang University (CN), University of Cincinnati Medical Center (US)
University of Cincinnati, National Natural Science Foundation of China, National Key Research and Development Program of China, Natural Science Foundation of Zhejiang Province
Openalex Percentile: Top 14%
Graphene and Nanomaterials Applications
2.02
DOISourceOpenAlex
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