Immunomodulatory and cardio-protective effects of differentially originated multipotent mesenchymal stroma cells during polymicrobial sepsis in mice
CLP-induced polymicrobial sepsis in mice was associated with cardiac damage and increased inflammation in left ventricular tissue. Therapeutic systemic application of human BMMSC and ASC ameliorated damage and inflammation in the heart.
Authors
- Anna Kanewska
- Markus Rojewski (ORCID: https://orcid.org/0000-0003-4265-0442)
- Jochen Preßmar
- Martina Winkelmann
- Anne Friedrich (ORCID: https://orcid.org/0000-0003-3558-9356)
- Ina Lackner (ORCID: https://orcid.org/0000-0001-6410-9222)
- Miriam Kalbitz (ORCID: https://orcid.org/0000-0002-1474-0785)
- Hubert Schrezenmeier (ORCID: https://orcid.org/0000-0003-1222-6659)
- Birte Weber (ORCID: https://orcid.org/0009-0006-3354-0304)
- Mario Perl (ORCID: https://orcid.org/0000-0002-5768-3688)
Institutions
- Goethe University Frankfurt (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universität Ulm (DE)
- Military Hospital (PK)
- German Red Cross (DE)
- Universitätsklinikum Erlangen (DE)
- University Hospital Frankfurt (DE)
Publication Details
- Journal
- European Journal of Trauma and Emergency Surgery
- Published
- 2025-04-20
- DOI
- https://doi.org/10.1007/s00068-025-02862-2
- Citations
- 1
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Deutsche Forschungsgemeinschaft
- Else Kröner-Fresenius-Stiftung
- Universitätsklinikum Erlangen