Effect of PVP and HPMC on production of indomethacin amorphous nanoparticles: experiments and molecular dynamics simulations
PVP contributed to maintain the amorphous state during the milling process, which resulted from the higher molecular binding energy compared to HPMC. Controlled milling of amorphous SD with optimized polymer selection could simultaneously achieve nanoamorphous particle and enhanced dissolution rate.
Authors
- Haiyun Tian
- Haosen Zhang
- Tao Liu (ORCID: https://orcid.org/0009-0005-5108-4309)
- Tingting Yang (ORCID: https://orcid.org/0000-0003-4272-2151)
- Tianwei Zhang (ORCID: https://orcid.org/0000-0002-1462-5402)
- Wenhui Zhou (ORCID: https://orcid.org/0000-0001-5344-7285)
- Mengmeng Han (ORCID: https://orcid.org/0000-0003-4801-0585)
Institutions
- Qingdao University of Science and Technology (CN)
- Yunnan University (CN)
Publication Details
- Journal
- Drug Development and Industrial Pharmacy
- Published
- 2025-04-20
- DOI
- https://doi.org/10.1080/03639045.2025.2495136
- Citations
- 1
- Primary Topic
- Drug Solubulity and Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.79