Dietary Fat Promotes Triple-Negative Breast Cancer through FABP5–mTOR

Major Finding: Dietary ω-6 linoleic acid (LA) promotes oncogenic mTOR signaling in triple-negative breast cancer (TNBC).Concept: TNBCs express the fatty acid binding protein FABP5, which senses ω-6 LA and promotes mTOR-Raptor complex function.Impact: This study highlights FABP5 as a functional link between dietary fat and TNBC that warrants further investigation.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-039
Primary Topic
Cancer, Lipids, and Metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

Dietary Fat Promotes Triple-Negative Breast Cancer through FABP5–mTOR

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Cancer Discovery
Cancer, Lipids, and Metabolism
article

Dietary Fat Promotes Triple-Negative Breast Cancer through FABP5–mTOR

article en

Abstract

Major Finding: Dietary ω-6 linoleic acid (LA) promotes oncogenic mTOR signaling in triple-negative breast cancer (TNBC).Concept: TNBCs express the fatty acid binding protein FABP5, which senses ω-6 LA and promotes mTOR-Raptor complex function.Impact: This study highlights FABP5 as a functional link between dietary fat and TNBC that warrants further investigation.

Cancer Discovery
Zero hunger
Openalex Percentile: Top 91%
Cancer, Lipids, and Metabolism
DOISourceOpenAlex
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Dietary Fat Promotes Triple-Negative Breast Cancer through FABP5–mTOR · Cancer Discovery (2025) | TGRS Research Map | TGRS