ROS Sensing Regulates Mitochondrial Translation and Chemotherapy Response

Major Finding: ROS levels regulate retromer activity, influencing mitochondrial translation and chemotherapy response.Concept: VPS35 cysteine oxidation decreases SLC7A1-mediated arginine import and mitochondrial tRNA charging.Impact: VPS35 levels and oxidation state may reflect tumor sensitivity to ROS-modulating chemotherapies.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-040
Primary Topic
Nitric Oxide and Endothelin Effects
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

ROS Sensing Regulates Mitochondrial Translation and Chemotherapy Response

Cancer Discovery
Nitric Oxide and Endothelin Effects
article

ROS Sensing Regulates Mitochondrial Translation and Chemotherapy Response

article en

Abstract

Major Finding: ROS levels regulate retromer activity, influencing mitochondrial translation and chemotherapy response.Concept: VPS35 cysteine oxidation decreases SLC7A1-mediated arginine import and mitochondrial tRNA charging.Impact: VPS35 levels and oxidation state may reflect tumor sensitivity to ROS-modulating chemotherapies.

Cancer Discovery
Zero hunger
Openalex Percentile: Top 90%
Nitric Oxide and Endothelin Effects
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

ROS Sensing Regulates Mitochondrial Translation and Chemotherapy Response · Cancer Discovery (2025) | TGRS Research Map | TGRS