Aqueous humour concentrations of <scp>HB</scp> ‐ <scp>EGF</scp> , <scp>EGF</scp> and <scp>VEGF</scp> ‐A and axial length in humans
With the concentrations of HB-EGF and EGF increasing with longer axial length, the study supports a potential role of the EGFR signalling pathway activation in human axial myopia. The inverse relationship between VEGF-A concentration and longer axial length agrees with a protective effect of axial myopia against diabetic retinopathy and age-related macular degeneration.
Authors
- Yongan Andrew Yang (ORCID: https://orcid.org/0000-0003-1451-2923)
- Rui‐Heng Zhang
- Wen‐Da Zhou
- Yuan He (ORCID: https://orcid.org/0000-0001-7692-5577)
- Li Dong (ORCID: https://orcid.org/0000-0003-0120-5756)
- Hanqing Zhao (ORCID: https://orcid.org/0000-0003-0327-3699)
- Jost Bruno Jonas (ORCID: https://orcid.org/0000-0003-2972-5227)
- Xiaozhen Wang (ORCID: https://orcid.org/0000-0003-0088-3221)
- Wenbin Wei (ORCID: https://orcid.org/0000-0003-2386-0989)
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Singapore National Eye Center (SG)
- New York Eye and Ear Infirmary (US)
- Singapore Eye Research Institute (SG)
- Fondation de Rothschild (FR)
- Beijing Tsinghua Chang Gung Hospital (CN)
- Ministry of Industry and Information Technology (CN)
- Icahn School of Medicine at Mount Sinai (US)
- Tsinghua University (CN)
Publication Details
- Journal
- Acta Ophthalmologica
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1111/aos.17504
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China