CLINICAL, RADIOLOGICAL AND HISTOPATHOLOGICAL FEATURES OF MENETRIER'S DISEASE: A CASE REPORT

Introduction: Menetrier's disease is a rare gastric disorder marked by enlarged gastric folds, excessive mucus secretion, and protein loss, often leading to hypoalbuminemia. Its exact cause remains unclear, though associations with Helicobacter pylori infection and Transforming Growth Factor-Alpha (TGF-α) overexpression have been reported. We report a case of a 49- year-old male pres Case Report: enting with chronic abdominal discomfort, weight loss, and diarrhea. Laboratory investigations revealed hypoproteinemia, while imaging and endoscopic findings showed thickened gastric folds. Histopathology confirmed the diagnosis. The patient was managed conservatively with octreotide and proton pump inhibitors, with periodic endoscopic surveillance advised due to the potential for malignant transformation. Menetrier's disease Discussion: is often misdiagnosed due to its overlapping features with other gastric pathologies, including Zollinger-Ellison syndrome and malignancies. Diagnostic confirmation requires a combination of clinical, radiological, and histopathological assessments. Treatment strategies range from medical management to total gastrectomy in severe cases. Given its rarity and potential complication Conclusion: s, Menetrier's disease should be considered in patients presenting with hypertrophic gastric folds and protein loss. Early recognition and long-term monitoring are crucial for optimal management and to mitigate the risk of gastric adenocarcinoma.