High-Dose Versus Standard-Dose Twice-Daily Thoracic Radiotherapy in Limited-Stage SCLC: Final Survival Data, Long-Term Toxicity, and Relapse Patterns in a Randomized, Open-Label, Phase II Trial

Twice-daily TRT of 60 Gy/40 fractions was well tolerated and prolonged survival compared with 45 Gy/30 fractions in patients with limited-stage SCLC. This trial is registered at ClinicalTrials.gov: NCT02041845.

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Publication Details

Journal
Journal of Thoracic Oncology
Published
2025-04-19
DOI
https://doi.org/10.1016/j.jtho.2025.04.007
Citations
5
Primary Topic
Lung Cancer Research Studies
Type
article
Field-Weighted Citation Impact
5.23

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article

High-Dose Versus Standard-Dose Twice-Daily Thoracic Radiotherapy in Limited-Stage SCLC: Final Survival Data, Long-Term Toxicity, and Relapse Patterns in a Randomized, Open-Label, Phase II Trial

Jens Engleson, Tine Schytte, Kirill Neumann, Nina Helbekkmo et al.
5 citations
Journal of Thoracic Oncology
Lung Cancer Research Studies
5.23
article

High-Dose Versus Standard-Dose Twice-Daily Thoracic Radiotherapy in Limited-Stage SCLC: Final Survival Data, Long-Term Toxicity, and Relapse Patterns in a Randomized, Open-Label, Phase II Trial

Jens Engleson, Tine Schytte, Kirill Neumann, Nina Helbekkmo, Maria Moksnes Bjaanæs, Sverre Fluge, Tarje Onsøien Halvorsen, Thor Naustdal, Liv Giske, Odd Terje Brustugun, Øyvind Yksnøy, Tesfaye Madebo, Seppo W. Langer, Signe Lenora Risumlund, Kristin Toftaker Killingberg, Georgios Tsakonas, Øystein Fløtten, Jan Nyman, Bjørn Henning Grønberg
article en
5 citations

Abstract

Twice-daily TRT of 60 Gy/40 fractions was well tolerated and prolonged survival compared with 45 Gy/30 fractions in patients with limited-stage SCLC. This trial is registered at ClinicalTrials.gov: NCT02041845.

Journal of Thoracic OncologyVol. 20(8)
Oslo University Hospital (NO), University Hospital of North Norway (NO), Karolinska University Hospital (SE), Lund University (SE), Norwegian University of Science and Technology (NO), Innlandet Hospital Trust (NO), Stavanger University Hospital (NO), Akershus University Hospital (NO), Drammen Hospital (NO), Levanger Hospital (NO), Vestre Viken Hospital Trust (NO), Haukeland University Hospital (NO), Sahlgrenska University Hospital (SE), Odense University Hospital (DK), Privatsykehuset Haugesund (NO), Copenhagen University Hospital (DK), Rigshospitalet (DK), Ålesund Hospital (NO), St Olav's University Hospital (NO), Skåne University Hospital (SE)
Norges Teknisk-Naturvitenskapelige Universitet
Good health and well-being
Openalex Percentile: Top 4%
Lung Cancer Research Studies
5.23
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