High-Dose Versus Standard-Dose Twice-Daily Thoracic Radiotherapy in Limited-Stage SCLC: Final Survival Data, Long-Term Toxicity, and Relapse Patterns in a Randomized, Open-Label, Phase II Trial
Twice-daily TRT of 60 Gy/40 fractions was well tolerated and prolonged survival compared with 45 Gy/30 fractions in patients with limited-stage SCLC. This trial is registered at ClinicalTrials.gov: NCT02041845.
Authors
- Jens Engleson
- Tine Schytte (ORCID: https://orcid.org/0000-0002-6705-1561)
- Kirill Neumann (ORCID: https://orcid.org/0009-0007-2513-0871)
- Nina Helbekkmo (ORCID: https://orcid.org/0000-0003-4748-4914)
- Maria Moksnes Bjaanæs (ORCID: https://orcid.org/0000-0001-7126-9064)
- Sverre Fluge
- Tarje Onsøien Halvorsen (ORCID: https://orcid.org/0000-0002-1181-921X)
- Thor Naustdal
- Liv Giske
- Odd Terje Brustugun (ORCID: https://orcid.org/0000-0002-5153-8391)
- Øyvind Yksnøy
- Tesfaye Madebo (ORCID: https://orcid.org/0000-0003-3043-5059)
- Seppo W. Langer (ORCID: https://orcid.org/0000-0001-9732-9192)
- Signe Lenora Risumlund
- Kristin Toftaker Killingberg (ORCID: https://orcid.org/0000-0002-1354-9823)
- Georgios Tsakonas (ORCID: https://orcid.org/0000-0003-4397-7391)
- Øystein Fløtten (ORCID: https://orcid.org/0000-0001-9265-6506)
- Jan Nyman (ORCID: https://orcid.org/0000-0002-2314-5902)
- Bjørn Henning Grønberg (ORCID: https://orcid.org/0000-0001-5744-1534)
Institutions
- Oslo University Hospital (NO)
- University Hospital of North Norway (NO)
- Karolinska University Hospital (SE)
- Lund University (SE)
- Norwegian University of Science and Technology (NO)
- Innlandet Hospital Trust (NO)
- Stavanger University Hospital (NO)
- Akershus University Hospital (NO)
- Drammen Hospital (NO)
- Levanger Hospital (NO)
- Vestre Viken Hospital Trust (NO)
- Haukeland University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Odense University Hospital (DK)
- Privatsykehuset Haugesund (NO)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Ålesund Hospital (NO)
- St Olav's University Hospital (NO)
- Skåne University Hospital (SE)
Publication Details
- Journal
- Journal of Thoracic Oncology
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1016/j.jtho.2025.04.007
- Citations
- 5
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.23
Funders
- Norges Teknisk-Naturvitenskapelige Universitet