Molecular correlates of glycine receptor activity in human β cells
We demonstrate that glucose can modulate GlyR expression, and that the current decrease in T2D is likely due to the receptor gene expression downregulation, and not a change in transcript splicing. Moreover, we define a previously unknown set of genes and regulons that are correlated to GlyR-mediated currents and could be involved in GlyR downregulation in T2D. Among those we validate the negative impact of EIF4EBP1 expression on GlyR activity.
Authors
- Patrick Edward MacDonald (ORCID: https://orcid.org/0000-0002-5439-6288)
- Aliya F Spigelman (ORCID: https://orcid.org/0000-0001-6188-2041)
- Kunimasa Suzuki (ORCID: https://orcid.org/0000-0003-0102-3493)
- Jasmine Maghera (ORCID: https://orcid.org/0000-0001-9208-7454)
- Theodore dos Santos (ORCID: https://orcid.org/0000-0002-9761-3609)
- Cara E. Ellis (ORCID: https://orcid.org/0000-0003-3234-8880)
- Amanda Schukarucha Gomes
Institutions
- University of Alberta (CA)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1016/j.molmet.2025.102156
- Citations
- 1
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Institutes of Health
- Canadian Institutes of Health Research