Evaluation of pharmacokinetics of intravenous protein C concentrate in protein C deficiency: implications for treatment initiation and maintenance
Age, body weight, and symptomatic disease state should be considered in dose optimization. Model-based simulations support the use of various combined loading and maintenance regimens to quickly and effectively achieve target protein C plasma levels.
Authors
- Inmaculada C. Sorribes (ORCID: https://orcid.org/0000-0001-8348-3746)
- Jennifer Schneider (ORCID: https://orcid.org/0000-0002-3473-8009)
- Zhaoyang Li (ORCID: https://orcid.org/0000-0002-2851-6506)
- Adekemi B. Taylor (ORCID: https://orcid.org/0000-0002-7373-5660)
Institutions
- Takeda (United States) (US)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.rpth.2025.102859
- Citations
- 2
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.54