Neuromuscular electrical stimulation reduces spinal excitability in Multiple Sclerosis patients with spasticity symptoms
The reduction of H-reflex after pNMES and NMES+ can be attributed to a reduced spinal excitability in spastic MS patients, which may be attributed to presynaptic inhibition, recurrent inhibition, gamma-aminobutyric acid activity and persistent inward current. These results are highly relevant from both neurophysiological and clinical point of views, suggesting new approaches to manage spasticity symptoms in neurological patients.
Authors
- Andrea Macaluso (ORCID: https://orcid.org/0000-0001-9029-6156)
- Fabrizia Monteleone
- Francesco Sica (ORCID: https://orcid.org/0000-0002-7255-952X)
- Riccardo Borzuola (ORCID: https://orcid.org/0000-0001-6945-5132)
- Martina Scalia (ORCID: https://orcid.org/0000-0002-3305-2435)
- Giovanna Borriello (ORCID: https://orcid.org/0000-0001-6825-3889)
- Martina Parrella
Institutions
- Foro Italico University of Rome (IT)
- Fatebenefratelli Hospital (IT)
- Ospedale Santa Maria Goretti (IT)
Publication Details
- Journal
- Multiple Sclerosis and Related Disorders
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1016/j.msard.2025.106457
- Citations
- 1
- Primary Topic
- Botulinum Toxin and Related Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.39