Evaluating the return of additional findings from the 100,000 Genomes Project: A mixed-methods study exploring participant experiences of receiving secondary findings from genomic sequencing
Patient experiences of receiving AFs were primarily positive, and there is support for offering AFs routinely. Considerations for offering AFs in clinical practice include adapting approaches tailored to individual conditions and greater support for people with a NAF result.
Authors
- Paul Brennan (ORCID: https://orcid.org/0000-0002-0518-8714)
- Lara Hawkes
- Jana Gurasashvili
- Louise Dubois
- Elaine George
- Angela George (ORCID: https://orcid.org/0000-0002-4295-7287)
- Blanche Griffin
- Deborah Holiday
- Meena Balasubramanian (ORCID: https://orcid.org/0000-0003-1488-3695)
- Emma Smith (ORCID: https://orcid.org/0000-0002-2144-8790)
- Philandra Costello
- Lyn S. Chitty (ORCID: https://orcid.org/0000-0002-4857-7138)
- Lucy Bownass (ORCID: https://orcid.org/0000-0003-3114-4632)
- Melissa K. Hill (ORCID: https://orcid.org/0000-0003-3900-1425)
- Elizabeth A. V. Jones (ORCID: https://orcid.org/0000-0002-2006-7064)
- Steve E. Humphries (ORCID: https://orcid.org/0000-0002-8221-6547)
- Stephen Morris (ORCID: https://orcid.org/0000-0002-6628-5809)
- Bianca DeSouza (ORCID: https://orcid.org/0000-0003-0686-3838)
- Ben Paternoster (ORCID: https://orcid.org/0000-0003-0775-6874)
- Vishakha Tripathi (ORCID: https://orcid.org/0000-0001-8118-8364)
- Ruth Cleaver (ORCID: https://orcid.org/0000-0002-5987-3813)
- Amy E. Taylor (ORCID: https://orcid.org/0000-0003-1853-0563)
- Suresh Somarathi
- Michelle Peter (ORCID: https://orcid.org/0000-0002-4977-8708)
- Bethany Stafford‐Smith
- Morgan Daniel (ORCID: https://orcid.org/0000-0002-4455-5521)
- Rachel Harrison
- Alison Kraus
- Virginia Clowes
- Alan Jones
- Meriel McEntagart
- Rashida Baptiste
- Bethany Lumborg
- Xavier Bracke-Manzanares
- Lamprini Georgiou
- Adele Green-Armytage
Institutions
- University Hospitals Birmingham NHS Foundation Trust (GB)
- Royal Marsden NHS Foundation Trust (GB)
- Nottingham University Hospitals NHS Trust (GB)
- University of Liverpool (GB)
- St George's, University of London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- University of Cambridge (GB)
- Chapel Allerton Hospital (GB)
- Royal Devon & Exeter NHS Foundation Trust (GB)
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- London North West Healthcare NHS Trust (GB)
- University Hospitals Bristol NHS Foundation Trust (GB)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Princess Anne Hospital (GB)
- Nuffield Orthopaedic Centre (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- St Mary's Hospital (GB)
- St Mary's Hospital (GB)
- Sheffield Children's NHS Foundation Trust (GB)
- St. Thomas Hospital (CA)
- Birmingham Women’s and Children’s NHS Foundation Trust (GB)
- Liverpool Womens NHS Foundation Trust (GB)
- University College London (GB)
Publication Details
- Journal
- Genetics in Medicine
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1016/j.gim.2025.101446
- Citations
- 1
- Primary Topic
- Genomics and Rare Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Institute for Health and Care Research
- British Heart Foundation
- Department of Health and Social Care
- University College London Hospitals NHS Foundation Trust