Thrombospondin-1 induces immunogenic cell death in human mucoepidermoid carcinoma MC-3 cells via the PERK/eIF2α signaling pathway: potential implications for tumor immunotherapy
TSP-1 induces ICD in MC-3 cells, accompanied by CRT exposure, potentially mediated through the activation of the PERK/eIF2α signaling pathway. These findings suggest that TSP-1 may have potential as an adjunct to chemotherapy for enhancing tumor immunotherapy.
Authors
- Lijuan Guo (ORCID: https://orcid.org/0000-0003-4978-3731)
- Pengcheng Huang (ORCID: https://orcid.org/0000-0003-2211-2217)
- Kaizhi Cai
- Huan Zhang (ORCID: https://orcid.org/0000-0002-2289-7707)
- Sen Yang (ORCID: https://orcid.org/0000-0002-3958-5574)
- Guan Li (ORCID: https://orcid.org/0000-0003-4196-0051)
- Zongyao Zhang (ORCID: https://orcid.org/0000-0001-8341-2614)
- Yixuan Zhu (ORCID: https://orcid.org/0009-0004-1400-3306)
Institutions
- North Sichuan Medical University (CN)
- Suizhou Central Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1007/s12672-025-02315-7
- Citations
- 1
- Primary Topic
- Phytochemistry and biological activity of medicinal plants
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- Department of Science and Technology of Sichuan Province
- Sichuan Provincial Administration of Traditional Chinese Medicine
- Chinese Stomatological Association
- Health Commission of Sichuan Province