Standard Dose Versus Reduced Dose Single Fraction Preoperative Radiosurgery for Resected Brain Metastases (PROPS-BM) International Multicenter Cohort Study
Both SD and RD single fraction preoperative SRS demonstrate excellent rates of cavity LR and ARE. Cavity LR risk increased with larger lesion size, regardless of SRS dose category. There does not seem to be an advantage in efficacy or toxicity for RD over SD single fraction preoperative SRS. Additional studies are warranted to optimize preoperative SRS dose and fractionation.
Authors
- Cristian Udovicich (ORCID: https://orcid.org/0000-0001-6093-5164)
- Susan Boyles
- Kailin Yang (ORCID: https://orcid.org/0000-0001-5968-6738)
- Jennifer K. Matsui (ORCID: https://orcid.org/0000-0003-0693-0404)
- Joshua D. Palmer (ORCID: https://orcid.org/0000-0003-3311-0129)
- Mark Vikas Mishra (ORCID: https://orcid.org/0000-0002-2588-1575)
- Alexander Ksendzovsky (ORCID: https://orcid.org/0000-0003-4547-8959)
- Haley Kopp Perlow (ORCID: https://orcid.org/0000-0001-8667-0782)
- Samuel T. Chao (ORCID: https://orcid.org/0000-0002-1087-2764)
- Tu Dan (ORCID: https://orcid.org/0000-0003-1154-0507)
- Roshan S. Prabhu (ORCID: https://orcid.org/0000-0001-6166-5768)
- Erin S. Murphy (ORCID: https://orcid.org/0000-0003-3724-8539)
- Zachary Vaslow
- Graeme F. Woodworth (ORCID: https://orcid.org/0000-0001-9663-0768)
- Zabi Wardak (ORCID: https://orcid.org/0000-0001-9007-8415)
- Anthony L. Asher (ORCID: https://orcid.org/0000-0002-3596-3849)
- Toral Patel (ORCID: https://orcid.org/0000-0002-3021-7361)
- Rachel Russek
- Neda Haghighi
- Stuart H. Burri
Institutions
- University of Maryland, Baltimore (US)
- Cone Health (US)
- Cleveland Clinic (US)
- Epworth Hospital (AU)
- Peter MacCallum Cancer Centre (AU)
- Carolina Neurosurgery and Spine Associates (US)
- Levine Cancer Institute (US)
- Southeast Radiation Oncology Group (US)
- U-M Rogel Cancer Center (US)
- The Ohio State University (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Advances in Radiation Oncology
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1016/j.adro.2025.101794
- Citations
- 1
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52