Astragaloside II, a natural saponin, facilitates remyelination in demyelination neurological diseases via p75NTR receptor mediated β-catenin/Id2/MBP signaling axis in oligodendrocyte precursor cells
AS-II represents a novel therapeutic candidate for demyelinating diseases, offering a targeted approach to myelin regeneration through direct p75NTR modulation and addressing gaps in current treatment strategies.
Authors
- Mengxue Wang (ORCID: https://orcid.org/0000-0002-0756-7427)
- Xiaojun Wu (ORCID: https://orcid.org/0000-0001-6554-5341)
- Fei Huang
- Jinfeng Yuan
- Hui Wu (ORCID: https://orcid.org/0000-0002-1465-5847)
- Yanlin Tao (ORCID: https://orcid.org/0000-0001-7315-6127)
- Hailin Shi (ORCID: https://orcid.org/0000-0002-3603-2683)
- Yufeng Chen (ORCID: https://orcid.org/0000-0003-2970-352X)
- Xinyan Han (ORCID: https://orcid.org/0009-0001-9575-1135)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1016/j.jare.2025.04.028
- Citations
- 2
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.64