Therapeutic potential of CHI3L1 in osteoarthritis: Inhibition of cartilage matrix degradation and inflammation through TLR4-MAPK-STAT1 pathway
We have established the protective role of CHI3L1 in maintaining cartilage matrix homeostasis, identified potential receptors and pathways associated with CHI3L1, and elucidated its mechanisms of action. The role of CHI3L1 in osteoarthritic synovial tissue has not yet been investigated. Further research is needed to elucidate the effects of CHI3L1 secreted by synovial tissue on chondrocytes.
Authors
- Yanjun Hou (ORCID: https://orcid.org/0000-0003-3077-670X)
- Chen Meng (ORCID: https://orcid.org/0000-0002-5968-6719)
- Xiaojian Huang (ORCID: https://orcid.org/0000-0003-0047-6343)
- Ruijia Zhou
- Hongbo You (ORCID: https://orcid.org/0000-0001-6284-643X)
- Yunkun Qu (ORCID: https://orcid.org/0000-0002-8529-0478)
- Sheng Chen (ORCID: https://orcid.org/0000-0003-1770-5018)
- Jie Li (ORCID: https://orcid.org/0000-0003-2343-1658)
- Qingyi Liu (ORCID: https://orcid.org/0009-0005-1180-966X)
- Hanqing Xu
- Yi He (ORCID: https://orcid.org/0000-0002-9882-4491)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1016/j.intimp.2025.114684
- Citations
- 5
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 8.34
Funders
- National Natural Science Foundation of China
- Wu Jieping Medical Foundation