Bioactive terpenoids and sterols from the fruiting bodies of Fomitopsis pinicola
A chemical investigation of the fruiting bodies of Fomitopsis pinicola was conducted, resulting in the isolation of 51 compounds, which included 16 previously undescribed lanostane triterpenes (1-14, 16-17), 30 known analogs (15, 18-46) as well as two sterols (47-48) and three diterpenes (49-51). Comprehensive analyses utilizing 1D, 2D NMR, MS and IR spectroscopy and DFT calculations of <sup>13</sup>C NMR chemical shifts have elucidated the structures of the compounds in question. Two undescribed compounds in addition to fomitosides F, G and K showed cytotoxicity against MCF-7 cell line with IC<sub>50</sub> values ranging from 11.01 to 31.92 μM. Meanwhile, these isolates showed α-glucosidase inhibitory activity, and compound 7 showed the IC<sub>50</sub> value of 9.22 μM.
Authors
- Xianghua Zhang (ORCID: https://orcid.org/0000-0002-2180-6543)
- Min Li (ORCID: https://orcid.org/0000-0002-2439-9656)
- Tingting Xu (ORCID: https://orcid.org/0000-0002-5920-808X)
- Dongli Zhang (ORCID: https://orcid.org/0000-0002-0556-5532)
- Pengfei Jin (ORCID: https://orcid.org/0000-0002-9461-0453)
- Huan Yu (ORCID: https://orcid.org/0000-0002-1360-6859)
- Yue Wang (ORCID: https://orcid.org/0009-0001-4220-0479)
- Qian Chen (ORCID: https://orcid.org/0000-0001-7355-714X)
- Shaoyong Li (ORCID: https://orcid.org/0000-0002-1614-4194)
- Wenlong Xu (ORCID: https://orcid.org/0000-0002-8657-5723)
- Sheng‐An Tang (ORCID: https://orcid.org/0000-0001-8473-0972)
- Chuan Zhao
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Phytochemistry
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1016/j.phytochem.2025.114510
- Citations
- 4
- Primary Topic
- Fungal Biology and Applications
- Type
- article
- Field-Weighted Citation Impact
- 5.58