Identification and validation of poor prognosis immunoevasive subtype of esophageal cancer with tumor-infiltrating SAMD3 + NK cell abundance
Our results demonstrate the predictive significance of NK cell markers in EC and pinpoint SAMD3 as a critical modulator of NK cell activity. We pioneer SAMD3 + NK cells as architects of TME immunosuppression in EC. Our findings nominate SAMD3 inhibition as a combinatorial strategy to overcome immune checkpoint blockade resistance.
Authors
- Qingle Wang (ORCID: https://orcid.org/0000-0001-9009-0035)
- Li Tan (ORCID: https://orcid.org/0000-0001-5961-0450)
- Xu Huang (ORCID: https://orcid.org/0000-0002-2276-3514)
- Shaoyuan Zhang (ORCID: https://orcid.org/0000-0002-6187-4313)
- Heng Jiao (ORCID: https://orcid.org/0000-0003-3805-9465)
- Zhaoyun Duan (ORCID: https://orcid.org/0000-0002-2179-5223)
- Mengyuan Wu (ORCID: https://orcid.org/0000-0001-9553-5718)
- Guoren Zhou (ORCID: https://orcid.org/0000-0001-5344-8480)
- Runze You
- Jun Yin (ORCID: https://orcid.org/0009-0008-5428-9969)
- Tiantao Sun
- Lin Miao
- Xinyu Yang (ORCID: https://orcid.org/0000-0001-5129-8781)
- Fangyi Liu (ORCID: https://orcid.org/0000-0002-8675-0798)
- Hao Yin (ORCID: https://orcid.org/0000-0002-2269-2250)
- Wenyi Xu (ORCID: https://orcid.org/0000-0001-7402-3916)
- Zitao Jian
- Han Tang
- Shuyi Yang
Institutions
- Shanghai Medical College of Fudan University (CN)
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1007/s00262-025-04028-w
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fudan University
- Science and Technology Commission of Shanghai Municipality
- Zhongshan Hospital
- Fujian Provincial Health Technology Project