Infrarenal Aortic Occlusion Causes Endothelial Injury via Mitochondrial Reactive Oxygen Species
To our knowledge this is the first study which demonstrates a successful therapeutic strategy in the treatment of endothelial glycocalyx shedding caused by aortic occlusion and hemorrhage in an animal model. Our study shows that glycocalyx shedding is attributable to mitochondrial ROS, and occurs following distal reperfusion rather than occlusion of the aorta or during hemorrhage. Consistent with findings in hemorrhagic shock, plasma succinate levels are elevated as a result of aortic occlusion and are upstream of ROS. Taken together, our findings suggest that in the setting of aortic occlusion, a therapeutic intervention could be performed prior to reperfusion which would substantially reduce injury to the vascular endothelium.
Authors
- Jacob Packer
- Sarah Abdullah (ORCID: https://orcid.org/0000-0001-6446-6684)
- Mardeen S. Karim (ORCID: https://orcid.org/0000-0003-4287-4745)
- Farhana Shaheen
- David Engelhardt (ORCID: https://orcid.org/0009-0005-1026-2869)
- Sharven Taghavi (ORCID: https://orcid.org/0000-0001-6289-2129)
- Juan Duchesne (ORCID: https://orcid.org/0000-0002-1490-1585)
- Aaron Cotton-Betteridge (ORCID: https://orcid.org/0000-0003-1143-7526)
- Jessica Friedman (ORCID: https://orcid.org/0000-0002-7822-9126)
- Michael Ghio (ORCID: https://orcid.org/0000-0001-9930-8731)
- Olan Jackson‐Weaver (ORCID: https://orcid.org/0000-0002-0545-0647)
Institutions
- Tulane University (US)
Publication Details
- Journal
- Journal of Surgical Research
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1016/j.jss.2025.03.023
- Citations
- 1
- Primary Topic
- Cardiac, Anesthesia and Surgical Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- American Heart Association