Pharmacokinetics and pharmacodynamics of sublingual microdosed lysergic acid diethylamide in healthy adult volunteers
This study provides a population pharmacokinetic model and LC-MS/MS assay that can inform clinical and bioequivalence studies. Relevant CYP genotypes should be studied in larger samples as combined potential biomarkers of response. Microdose-sensitive and reliable pharmacodynamic measures are needed.
Authors
- Suresh D Muthukumaraswamy (ORCID: https://orcid.org/0000-0001-7042-3920)
- Robin J. Murphy (ORCID: https://orcid.org/0000-0002-9571-0050)
- James D. Morse (ORCID: https://orcid.org/0000-0001-7500-0062)
- Soo Hee Jeong (ORCID: https://orcid.org/0000-0002-5984-1280)
- Rachael L. Sumner (ORCID: https://orcid.org/0000-0002-2652-4617)
Institutions
- University of Auckland (NZ)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1177/02698811251330747
- Citations
- 1
- Primary Topic
- Psychedelics and Drug Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.31
Funders
- Health Research Council of New Zealand