Multicomponent Synthesis Of 2, 4, 5-Triphenyl Imidazole Derivatives by Grinding Method

An efficient synthesis of 2,4,5-trisubstituted imidazoles is prepared by three component cyclocondensation of 1,2-dicarbonyl compounds, substituted aryl aldehydes and ammonium acetate in presence of PTSA as catalyst followed by grinding method . All the derivatives were analysed by advanced spectroscopic data viz; 1H NMR, 13C NMR and LCMS and the structure of the molecule determination of the derivations was calculated by elemental analysis. The scope and advantages this process is cost effectiveness of catalyst, easy work-up and purification of products by non-chromatographic methods, good to excellent yields and very short time reactions and The compounds are evaluated for their invitro anti-bacterial activity KEYWORDS: 2, 4, 5-triarylimidazoles, benzil, aromatic aldehydes, PTSA, Grinding method, Antibacterial activity