Cerebral Amyloid Angiopathy Is Associated With Higher <scp>R<sub>2</sub></scp> Relaxation Rate: An <scp>MRI</scp> and Pathology Study
This is to our knowledge the first investigation of the link between CAA and R<sub>2</sub>, one of the major contrast mechanisms in MRI. R<sub>2</sub> is sensitive to CAA-related brain abnormalities, primarily in moderate and severe stages of the disease. In vivo detection of CAA is an important challenge, and the present work contributes new knowledge that may aid toward this goal.
Authors
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0002-9482-1752)
- Md Tahmid Yasar
- Mahir Tazwar (ORCID: https://orcid.org/0000-0002-6270-8798)
- Konstantinos Arfanakis (ORCID: https://orcid.org/0000-0001-9705-597X)
- Arnold M Evia (ORCID: https://orcid.org/0000-0003-2262-890X)
- Sue E. Leurgans (ORCID: https://orcid.org/0000-0003-2536-1665)
Institutions
- Rush University Medical Center (US)
- Illinois Institute of Technology (US)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1002/acn3.70037
- Citations
- 1
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Rush University
- National Institutes of Health
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke