Sex‐ and region‐dependent neuroinflammation in Alzheimer's disease
We show that neuroinflammation in Alzheimer's disease (AD) is modulated by sex in a region-specific manner. Neuroinflammation was highest in the subiculum and significant only in women. Inflammatory microRNAs (miRNAs) increased in the parietal cortex of women, but not men, with AD. Deposition of tau was highest in the entorhinal cortex and significant in both sexes. Density of tau and TSPO was positively and significantly correlated only in AD women.
Authors
- Geidy E. Serrano
- Erin E. Sundermann (ORCID: https://orcid.org/0000-0001-5821-8035)
- Anat Biegon (ORCID: https://orcid.org/0000-0002-2696-5949)
- Vanessa Carter (ORCID: https://orcid.org/0000-0001-9271-0541)
- Jasbeer Dhawan
- Maricedes Acosta‐Martínez (ORCID: https://orcid.org/0000-0003-0841-4032)
- Dalfino John
- Aviram Nessim
- Thomas G. Beach
- Radha Panchal
Institutions
- Banner Health (US)
- University of California San Diego (US)
- Stony Brook School (US)
- Banner Sun Health Research Institute (US)
- Stony Brook University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/alz.14603
- Citations
- 8
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 9.31
Funders
- Michael J. Fox Foundation for Parkinson's Research
- Arizona Department of Health Services
- University of Washington
- Stony Brook University
- Arizona Biomedical Research Commission
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke