Molecular signatures define <i>BAP1</i>-altered meningioma as a distinct CNS tumor with deregulation of Polycomb repressive complex target genes
BAP1-altered meningiomas represent a distinct and aggressive CNS tumor subtype associated with PRC dysregulation and recurrent 3p chromosome loss. These findings support the designation "meningioma, BAP1-altered."
Authors
- Sybren L. N. Maas (ORCID: https://orcid.org/0000-0002-8745-4405)
- Annika K. Wefers (ORCID: https://orcid.org/0000-0001-9394-8519)
- Sandro M. Krieg (ORCID: https://orcid.org/0000-0003-4050-1531)
- Frank Szulzewsky (ORCID: https://orcid.org/0000-0001-5710-9590)
- Christian Johannes Hartmann (ORCID: https://orcid.org/0009-0004-3700-3536)
- Patrick N. Harter (ORCID: https://orcid.org/0000-0001-5530-6910)
- Till Acker (ORCID: https://orcid.org/0000-0001-6357-7227)
- Leonille Schweizer (ORCID: https://orcid.org/0000-0002-4649-2587)
- Daniel Schrimpf (ORCID: https://orcid.org/0000-0003-3063-2423)
- Christian Mawrin (ORCID: https://orcid.org/0000-0002-6677-3124)
- Romain Appay (ORCID: https://orcid.org/0000-0003-4545-6063)
- David Vonhören
- Felix Behling (ORCID: https://orcid.org/0000-0002-1083-1276)
- Jens Schittenhelm (ORCID: https://orcid.org/0000-0002-9168-6209)
- Rouzbeh Banan (ORCID: https://orcid.org/0000-0002-9999-576X)
- Stefan M. Pfister (ORCID: https://orcid.org/0000-0002-5447-5322)
- Philipp Sievers (ORCID: https://orcid.org/0000-0003-3237-6021)
- Pieter Wesseling (ORCID: https://orcid.org/0000-0001-5453-5201)
- Andreas von Deimling (ORCID: https://orcid.org/0000-0002-5863-540X)
- Rudi Beschorner (ORCID: https://orcid.org/0000-0003-1109-915X)
- Tibor Hortobágyi (ORCID: https://orcid.org/0000-0001-5732-7942)
- Felix Sahm (ORCID: https://orcid.org/0000-0001-5441-1962)
- Patricia Kohlhof‐Meinecke
- Eric C. Holland (ORCID: https://orcid.org/0000-0002-3792-7120)
- Matija Snuderl (ORCID: https://orcid.org/0000-0003-0752-0917)
- Wolfgang Wick (ORCID: https://orcid.org/0000-0002-6171-634X)
- Stefan Pusch (ORCID: https://orcid.org/0000-0002-3407-4249)
- Miriam Ratliff (ORCID: https://orcid.org/0000-0002-9464-6544)
- D. Savran (ORCID: https://orcid.org/0000-0002-2685-5600)
- Thomas Hielscher (ORCID: https://orcid.org/0000-0003-1277-310X)
- Sonali Arora (ORCID: https://orcid.org/0000-0002-6661-3024)
- Hans‐Georg Wirsching (ORCID: https://orcid.org/0000-0001-6254-4204)
- Martin Sill (ORCID: https://orcid.org/0000-0001-7616-7665)
- Ghazaleh Tabatabai (ORCID: https://orcid.org/0000-0002-3542-8782)
- David Jones (ORCID: https://orcid.org/0000-0002-2036-5141)
- Sebastian Brandner (ORCID: https://orcid.org/0000-0002-8635-7195)
- Andrey Korshunov (ORCID: https://orcid.org/0000-0001-9408-6578)
- Hildegard Dohmen
Institutions
- Goethe University Frankfurt (DE)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- University College London Hospitals NHS Foundation Trust (GB)
- Universität Hamburg (DE)
- German Cancer Research Center (DE)
- Justus-Liebig-Universität Gießen (DE)
- University of Zurich (CH)
- Aix-Marseille Université (FR)
- University of Utah (US)
- Heidelberg University (DE)
- Leiden University Medical Center (NL)
- Huntsman Cancer Institute (US)
- University Hospital Heidelberg (DE)
- University of Utah Hospital (US)
- LMU Klinikum (DE)
- University Hospital Regensburg (DE)
- Medizinische Hochschule Hannover (DE)
- NYU Langone Health (US)
- Fred Hutch Cancer Center (US)
- Institut de Neurophysiopathologie (FR)
- University Hospital of Zurich (CH)
- Center for Neuro-Oncology (US)
- University Medical Center Hamburg-Eppendorf (DE)
- National Center for Tumor Diseases (DE)
- Hopp Children's Cancer Center Heidelberg (DE)
- University Children's Hospital Tübingen (DE)
- Princess Máxima Center (NL)
- Cancer Research Center (US)
- University Hospital Frankfurt (DE)
- Bernstein Center for Computational Neuroscience Tübingen (DE)
- MRC Prion Unit (GB)
- NIHR Queen Square Dementia Biomedical Research Unit (GB)
- Hertie Institute for Clinical Brain Research (DE)
- Comprehensive Cancer Center Erlangen (DE)
- Erasmus MC Cancer Institute (NL)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- University Medical Centre Mannheim (DE)
- Frankfurt Cancer Institute (DE)
- Klinikum Stuttgart (DE)
- Hôpital de la Timone (FR)
- University College London (GB)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1093/neuonc/noaf105
- Citations
- 11
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 8.87