Molecular signatures define <i>BAP1</i>-altered meningioma as a distinct CNS tumor with deregulation of Polycomb repressive complex target genes

BAP1-altered meningiomas represent a distinct and aggressive CNS tumor subtype associated with PRC dysregulation and recurrent 3p chromosome loss. These findings support the designation "meningioma, BAP1-altered."

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Publication Details

Journal
Neuro-Oncology
Published
2025-04-18
DOI
https://doi.org/10.1093/neuonc/noaf105
Citations
11
Primary Topic
Chromatin Remodeling and Cancer
Type
article
Field-Weighted Citation Impact
8.87
Controls
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article

Molecular signatures define BAP1-altered meningioma as a distinct CNS tumor with deregulation of Polycomb repressive complex target genes

Sybren L. N. Maas, Annika K. Wefers, Sandro M. Krieg, Frank Szulzewsky et al.
11 citations
Neuro-Oncology
Chromatin Remodeling and Cancer
8.87
article

Molecular signatures define BAP1-altered meningioma as a distinct CNS tumor with deregulation of Polycomb repressive complex target genes

Sybren L. N. Maas, Annika K. Wefers, Sandro M. Krieg, Frank Szulzewsky, Christian Johannes Hartmann, Patrick N. Harter, Till Acker, Leonille Schweizer, Daniel Schrimpf, Christian Mawrin, Romain Appay, David Vonhören, Felix Behling, Jens Schittenhelm, Rouzbeh Banan, Stefan M. Pfister, Philipp Sievers, Pieter Wesseling, Andreas von Deimling, Rudi Beschorner, Tibor Hortobágyi, Felix Sahm, Patricia Kohlhof‐Meinecke, Eric C. Holland, Matija Snuderl, Wolfgang Wick, Stefan Pusch, Miriam Ratliff, D. Savran, Thomas Hielscher, Sonali Arora, Hans‐Georg Wirsching, Martin Sill, Ghazaleh Tabatabai, David Jones, Sebastian Brandner, Andrey Korshunov, Hildegard Dohmen
article en
11 citations

Abstract

BAP1-altered meningiomas represent a distinct and aggressive CNS tumor subtype associated with PRC dysregulation and recurrent 3p chromosome loss. These findings support the designation "meningioma, BAP1-altered."

Neuro-OncologyVol. 27(9)
Goethe University Frankfurt (DE), Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA), University College London Hospitals NHS Foundation Trust (GB), Universität Hamburg (DE), German Cancer Research Center (DE), Justus-Liebig-Universität Gießen (DE), University of Zurich (CH), Aix-Marseille Université (FR), University of Utah (US), Heidelberg University (DE), Leiden University Medical Center (NL), Huntsman Cancer Institute (US), University Hospital Heidelberg (DE), University of Utah Hospital (US), LMU Klinikum (DE), University Hospital Regensburg (DE), Medizinische Hochschule Hannover (DE), NYU Langone Health (US), Fred Hutch Cancer Center (US), Institut de Neurophysiopathologie (FR), University Hospital of Zurich (CH), Center for Neuro-Oncology (US), University Medical Center Hamburg-Eppendorf (DE), National Center for Tumor Diseases (DE), Hopp Children's Cancer Center Heidelberg (DE), University Children's Hospital Tübingen (DE), Princess Máxima Center (NL), Cancer Research Center (US), University Hospital Frankfurt (DE), Bernstein Center for Computational Neuroscience Tübingen (DE), MRC Prion Unit (GB), NIHR Queen Square Dementia Biomedical Research Unit (GB), Hertie Institute for Clinical Brain Research (DE), Comprehensive Cancer Center Erlangen (DE), Erasmus MC Cancer Institute (NL), National Hospital for Neurology and Neurosurgery (GB), Amsterdam University Medical Centers (NL), University Medical Centre Mannheim (DE), Frankfurt Cancer Institute (DE), Klinikum Stuttgart (DE), Hôpital de la Timone (FR), University College London (GB), University of Tübingen (DE), Ludwig-Maximilians-Universität München (DE), Otto-von-Guericke-Universität Magdeburg (DE)
Good health and well-being
Openalex Percentile: Top 2%
Chromatin Remodeling and Cancer
8.87
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