Highlights of 2024: The multifaceted roles of ILC3s in mucosal immunity and inflammation
In this article for the Highlights of 2024 Series, we discuss research on Group 3 innate lymphoid cells (ILC3s), which revealed their complex roles in mucosal immunity and inflammation. ILC3s can migrate from the gut to the kidneys, contributing to renal fibrosis. Their functions are metabolically regulated, with proteins such as nucleophosmin 1 and Tox2 influencing oxidative phosphorylation and glycolysis, respectively. ILC3s also express immune checkpoint molecules (e.g. cytotoxic T-lymphocyte antigen 4 and programmed cell death1), which modulate inflammation. These findings highlight the tissue-specific roles of ILC3s and the need for targeted immunotherapies.
Authors
- Shen Xin (ORCID: https://orcid.org/0000-0003-0597-4691)
- Xianzhi Gao (ORCID: https://orcid.org/0000-0002-3934-982X)
- Lie Wang (ORCID: https://orcid.org/0000-0001-5094-012X)
Institutions
- Communication University of Zhejiang (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Immunology and Cell Biology
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1111/imcb.70021
- Citations
- 1
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities