A new three‐dimensional model to describe human corneal oxygenation during contact lenses wear

The cornea can sustain normal metabolic processes (aerobic metabolism) if the oxygen levels at the cornea-tear film interface are within approximately 60-100 mmHg. This holds true for all of the contact lenses tested here under open-eye conditions. However, when the eyes are closed, the cornea is unable to maintain normal metabolic processes, leading to a shift towards anaerobic metabolism. Prolonged exposure to these conditions can cause corneal oedema (swelling) due to an inadequate oxygen supply.