The efficacy of 5-aminolevulinic acid photodynamic therapy in inducing cell death in multidrug-resistant Trichophyton mentagrophytes: An in vivo and in vitro study
These findings suggest that ALA-PDT disrupts the cell membrane, cell wall and internal cellular structure of T. mentagrophytes through increasing the release of Reactive Oxygen Species (ROS), thereby facilitating the elimination of the fungus. This research highlights the therapeutic potential of ALA-PDT as an innovative strategy for managing fungal infections, particularly those resistant to conventional treatments.
Authors
- Dongmei Shi (ORCID: https://orcid.org/0000-0002-0886-4191)
- Jinke Zhang (ORCID: https://orcid.org/0000-0003-0301-6166)
- Yuanyuan Liu (ORCID: https://orcid.org/0000-0002-7273-0358)
- Dongmei Li (ORCID: https://orcid.org/0000-0001-9140-2483)
- Sisi Wang (ORCID: https://orcid.org/0000-0002-3665-7835)
- Yanrui Chen
- Yiyang Weng
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Shandong University (CN)
- Georgetown University (US)
- Georgetown University Medical Center (US)
- Jining First People's Hospital (CN)
- Jining Medical University (CN)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1016/j.pdpdt.2025.104599
- Citations
- 3
- Primary Topic
- Plant Pathogens and Fungal Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.45