Peptides based on the interface of hnRNPA2B1-transthyretin complex repress retinal angiogenesis in diabetic retinopathy
Our findings demonstrated that under hyperglycemia, THIP-4 suppressed DR progression via the STAT4/miR-223-3p/FBXW7 and Notch1/Akt/mTOR axes both in vitro and in vivo. These results indicated that THIP-4 has strong potential for clinical application in DR and other angiogenesis associated diseases.
Authors
- Yixiu Chen (ORCID: https://orcid.org/0000-0002-9173-7651)
- Jun Shao (ORCID: https://orcid.org/0000-0003-3477-4568)
- Steve W. Cui (ORCID: https://orcid.org/0000-0001-5864-4544)
- Lu Ye (ORCID: https://orcid.org/0009-0003-7506-2847)
- Yu Xin (ORCID: https://orcid.org/0000-0002-5396-4319)
Institutions
- Jiangnan University (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1186/s12967-025-06437-y
- Citations
- 2
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 3.24
Funders
- China Postdoctoral Science Foundation