Transient intracellular expression of PD-L1 and VEGFR2 bispecific nanobody in cancer cells inspires long-term T cell activation and infiltration to combat tumor and inhibit cancer metastasis
PD-L1 and VEGFR2- bispecific V<sub>H</sub> intracellular nanobody was highly biocompatible and showed the potential for combined anti-cancer therapy through long-term immune activation mediated by PD-L1/PD-1 checkpoint blockade and anti-metastasis mediated by VEGFR2 blockade.
Authors
- Shuzhi Tang (ORCID: https://orcid.org/0000-0001-6616-9018)
- Chaohua Hu
- Yunfeng Lin (ORCID: https://orcid.org/0000-0003-1224-6561)
- Zhe‐Sheng Chen (ORCID: https://orcid.org/0000-0002-8289-097X)
- Xin-Yi Shangguan
- Zunfu Ke (ORCID: https://orcid.org/0000-0002-6251-7246)
- Zhuo Chen (ORCID: https://orcid.org/0000-0002-6351-8689)
- Yanan Wang (ORCID: https://orcid.org/0000-0001-7401-047X)
- Hu Li (ORCID: https://orcid.org/0000-0002-0511-2250)
- Lei Zhang (ORCID: https://orcid.org/0000-0003-1215-6486)
- Ping Hu (ORCID: https://orcid.org/0000-0001-8832-1391)
- Jincan Chen (ORCID: https://orcid.org/0000-0002-2944-4102)
Institutions
- St. John's University (US)
- Chinese Academy of Sciences (CN)
- Fujian Institute of Research on the Structure of Matter (CN)
- Fujian Agriculture and Forestry University (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1186/s12943-025-02253-6
- Citations
- 11
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 14.96
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Natural Science Foundation of Fujian Province
- Fujian Institute of Research on the Structure of Matter
- National Key Research and Development Program of China