HPV16 E7 inhibits HBD2 expression by down-regulation of ASK1-p38 MAPK pathway in cervical cancer
Our results implied that HPV16 E7 suppresses HBD2 expression via the inhibition of the ASK1-p38 MAPK signaling pathway, and this mechanism might be a key way of anti-tumor effect of Anisomycin. This study provided a novel insight into the expression and regulation mechanism of HBD2 in tumors and offered a possible therapeutic strategy by using defensins for cervical cancer in future.
Authors
- Xiaotian Huang (ORCID: https://orcid.org/0000-0003-1145-8386)
- Ren Ping Liu (ORCID: https://orcid.org/0000-0001-7001-6305)
- Qing Shi (ORCID: https://orcid.org/0000-0003-1934-0833)
- Lixia Jiang (ORCID: https://orcid.org/0000-0001-9390-7880)
- Bowen Shi (ORCID: https://orcid.org/0000-0002-4753-7572)
- Shanshan Deng (ORCID: https://orcid.org/0000-0001-9617-618X)
- Meizhen Wang (ORCID: https://orcid.org/0000-0002-3794-465X)
- Yingying Yin (ORCID: https://orcid.org/0000-0002-2518-7751)
- Yanli Cao
- Juanjuan Liao
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- First Affiliated Hospital of Gannan Medical University (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1186/s12985-025-02731-9
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China