The first trimester human placenta responds to Zika virus infection inducing an interferon (IFN) and antiviral interferon stimulated gene (ISG) response
Together these data show that first trimester placenta is susceptible to ZIKV infection which induces a delayed type III IFN antiviral response. This delay likely creates an environment favourable to ZIKV replication and dissemination across the early gestation placenta to fetal tissue, causing pathologies associated with congenital ZIKV syndrome.
Authors
- Kylie H. Van der Hoek (ORCID: https://orcid.org/0000-0002-7904-7340)
- Nicholas S. Eyre (ORCID: https://orcid.org/0000-0002-5424-7573)
- Claire Trelford Roberts (ORCID: https://orcid.org/0000-0002-9250-2192)
- Rosa C. Coldbeck-Shackley
- Dylan McCullough (ORCID: https://orcid.org/0000-0002-4510-3797)
- Tanja Jankovic‐Karasoulos (ORCID: https://orcid.org/0000-0003-4293-359X)
- Michael R. Beard (ORCID: https://orcid.org/0000-0002-4106-1016)
Institutions
- Flinders University (AU)
- Adelaide Institute for Sleep Health (AU)
- The University of Adelaide (AU)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-04-19
- DOI
- https://doi.org/10.1186/s12985-025-02729-3
- Citations
- 2
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Flinders University
- University of Adelaide
- Medical Research Council
- National Health and Medical Research Council