Nocebo Effect on Pain‐Related Autonomic Responses in a State of Experimentally‐Induced Sensitization
This study showed a facilitatory effect of negative expectation on enhanced pain-related autonomic responses in a state of experimentally-induced sensitisation in healthy participants. Hence, pain-related autonomic responses are shaped by both bottom-up (nociceptive input) and top-down (expectation) modulatory processes. This leads to the clinical implication that increased pain-related autonomic responses reported in individuals with chronic pain might not solely reflect pain hypersensitivities through nociceptive sensitisation, but also exaggerated negative expectation.
Authors
- Michèle Hubli (ORCID: https://orcid.org/0000-0001-6054-3283)
- Jan Rösner (ORCID: https://orcid.org/0000-0002-1973-1773)
- Paulina S. Scheuren (ORCID: https://orcid.org/0000-0001-7568-0133)
- Thomas Egger (ORCID: https://orcid.org/0000-0003-2125-4678)
- Florin Allmendinger (ORCID: https://orcid.org/0000-0001-7241-565X)
Institutions
- University of British Columbia (CA)
- University of Zurich (CH)
- Aarhus University (DK)
- Universitätsklinik Balgrist (CH)
- International Collaboration On Repair Discoveries (CA)
- Danish Pain Research Center (DK)
Publication Details
- Journal
- European Journal of Pain
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1002/ejp.70029
- Primary Topic
- Pain Management and Placebo Effect
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Michael Smith Health Research BC
- International Foundation for Research in Paraplegia
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Lundbeckfonden
- Universität Zürich
- H. Lundbeck A/S