Alkbh5 promotes Ythdf1 expression through demethylation thereby facilitating Fth1 translation to inhibit ferroptosis of myocardial infarction
This study demonstrates that Alkbh5 ameliorates MI by inhibiting ferroptosis through m6A demethylation of Fth1. These findings provide novel insights into the molecular mechanisms underlying MI and highlight potential therapeutic targets for MI treatment.
Authors
- Min Yin (ORCID: https://orcid.org/0000-0003-2540-9016)
- Heping Liu
Institutions
- Heilongjiang Provincial Hospital (CN)
Publication Details
- Journal
- BMC Cardiovascular Disorders
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1186/s12872-025-04749-x
- Citations
- 4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.22