Host Genetic Factors in Q Fever Susceptibility
Several indirect findings suggest that host-related factors influence susceptibility to <i>Coxiella burnetii</i> infection. We decided to explore the influence of genetic factors related to both innate and adaptive immunity in acute Q fever susceptibility. TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) polymorphisms, along with HLA-DRB1 alleles, were analyzed for 38 patients with acute Q fever, 38 matched controls, and 121 blood donors. No significant associations were found for TLR polymorphisms. However, HLA-DRB1*04 was more frequent in patients. HLA-DRB1 variants may play a role in Q fever susceptibility, supporting the need for further investigation into their potential implications for vaccination and risk assessment.
Authors
- Olga Montes‐Ares (ORCID: https://orcid.org/0000-0001-7109-8576)
- José Bordón (ORCID: https://orcid.org/0000-0003-4705-6901)
- Michele Hernández-Cabrera (ORCID: https://orcid.org/0000-0003-1908-8113)
- Elena Pisos-Álamo (ORCID: https://orcid.org/0000-0002-6376-6586)
- Cristina Carranza‐Rodriguez (ORCID: https://orcid.org/0000-0002-2768-0072)
- José-Luís Pérez-Arellano (ORCID: https://orcid.org/0000-0002-2936-8242)
- Alberto Torio-Ruiz
Institutions
- Universidad de Las Palmas de Gran Canaria (ES)
- Hospital Universitario Insular de Gran Canaria (ES)
- Hospital Universitario de Gran Canaria Doctor Negrín (ES)
- Hospital General Universitario de Albacete (ES)
- Hospital Universitario Virgen de la Arrixaca (ES)
Publication Details
- Journal
- Pathogens
- Published
- 2025-04-18
- DOI
- https://doi.org/10.3390/pathogens14040394
- Primary Topic
- Vector-borne infectious diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00