Gubi Decoction Ameliorates Porous Cartilage Endplate in an Intervertebral Disc Degeneration Model Mouse Through Inhibition of NF-κB Activity and Pyroptosis
In summary, GBD can effectively inhibit the activation of NF-κB signaling and pyroptosis of ECP, relieve the porosity of ECP, and then delay the IVDD process. GBD may serve as a potential therapeutic agent for IVDD treatment.
Authors
- Hanbing Zeng
- Sai Yao
- Hongfeng Ruan (ORCID: https://orcid.org/0000-0001-8868-9313)
- Lianguo Wu (ORCID: https://orcid.org/0009-0001-1378-1120)
- Yanan Li (ORCID: https://orcid.org/0000-0002-1392-526X)
Institutions
- Zhejiang Chinese Medical University (CN)
- Shanghai Medical College of Fudan University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/jir.s492365
- Citations
- 5
- Primary Topic
- Medicinal plant effects and applications
- Type
- article
- Field-Weighted Citation Impact
- 11.91