Mental Health Disorders Following Exposure to Endocrine Disruptor Chemicals

There is growing scientific concern regarding how endocrine-disrupting chemicals (EDCs) impact central nervous system (CNS) disorders. Both anecdotal and preclinical studies suggest a link between EDC exposure and major depressive disorder (MDD), potentially leading to neurodegenerative outcomes. EDCs primarily exhibit their biological effects by interacting with hormone receptors. Nonetheless, there is scientific evidence pointing to dysfunction in the hypothalamic-pituitary-gonadal-adrenal axis, which is linked to neuropsychiatric conditions. Additionally, the global incidence of MDD has risen. Various factors like gender, genetic components, age, hormonal balance, and cultural influences may explain differences in MDD prevalence. Recently, environmental pollutants such as industrial chemicals, emollients, plastics, fungicides, and pesticides have emerged as critical factors influencing this disorder. This review delves into the influence of key phthalate and bisphenol compounds on chronic inflammation and MDD.