A Time Adjustable Pulsatile Release System of Ketoprofen by Combination of Floating Drug Delivery and a Novel Natural Pulsatile Polymer

Back ground: Rheumatoid atritis is an inflammatory diesease related to joints and its symptoms worsen in the early morning. The aim of the current work was to formulate and evaluate pulsatile drug release Ketoprofen tablets by both natural and synthetic polymers and to get a required lag time o for the drug release at which the symptoms of the arthritis worsen. Methods: A gum was prepared from delonix regia seeds and used for pulsatile release. The Peanut husk powder was used as floating polymer. Direct compression method was used to prepare Core tablets. Core tablets were coated with delonix regia gum, HPMC and ethylcellulose for timed release. These pulsatile tablets were coated with floating polymers to improve lag time. Compression coated tablets were evaluated for hardness, friability, floating time, percent drug release and lag time. Results: Core tablets and compression tablets were shown adequate pharmaceutical properties. The core tablets (F3, F4) in which dehydrated banana powder used as superdisintegrant disintegrated within 20sec. The tablets coated with floating layer has shown improved lag time and shown a burst drug release of 80% after 4hrs. Conclusion: The core tablets of the formulation contain dehydrated banana powder as super disintegrant disintegrates within 30sec and Delonix regia gum alone shown required lag time fro burst drug release. The work has concluded that the mucilage from delonix has potential applications in pulsatile drug delivery.